Section 09 of 09 • 12 insights
Hormone Health
Your labs say "normal." You feel anything but normal.
How your body actually produces, converts, and responds to hormones.
From the report
The biology this section covers.
Hormones are your body's internal messengers. They travel through your bloodstream, coordinating everything from how you handle stress to how well you sleep, recover from a workout, manage your weight, and regulate your mood. Think of them as conductors in an orchestra: when they're in balance, everything works in harmony. When one is off, it can throw the whole system out of tune.
The story this section tells
What your DNA is doing under the hood. Why it matters today.
Standard labs measure hormone levels. They don’t show conversion, receptor sensitivity, or clearance rates.
You'll discover what your labs have been missing—the conversion, sensitivity, and clearance patterns that finally clarify why you feel the way you do.
This one is for you if…
Labs are "normal," but you're still exhausted, moody, or gaining weight.
What you'll see in your Hormone Health report.
Every insight below appears as a personalized dark card in your full Mosaic report, with a color marker tuned to your specific genetic variants and a practical next step you can act on.
Thyroid
4 insights
hormone health
Autoimmune Thyroid Risk
Genetic predisposition to Hashimoto's or Graves' varies widely. If you're in the higher-risk group, early antibody monitoring can catch the process years before full disease expression—when lifestyle interventions still have leverage.
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DIO1 Activity
DIO1 handles the body-wide conversion of inactive T4 into active T3. Reduced activity is a common reason for persistent hypothyroid symptoms—fatigue, weight gain, cold intolerance—even when TSH looks "normal." Standard testing misses this entirely.
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DIO2 Activity
DIO2 produces T3 specifically in the brain and muscles. Low activity is one of the most common causes of brain fog and cold hands on standard thyroid treatment that looks fine on paper. If your labs are normal but you still feel terrible, this is often why.
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Thyroid Stimulating Hormone (TSH) Levels
Your individual optimal TSH is often narrower than the lab reference range. Someone who feels best at 1.0 will feel terrible at 3.5—even though both are "normal." Knowing your sweet spot ends years of being told "you're fine" when you're clearly not.
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Cortisol
2 insights
hormone health
Cortisol Production
Some people run naturally high on cortisol; others trend low. Neither is inherently bad—but each benefits from different stress-management strategies. High producers need more active recovery; low producers may need adaptogen support. One-size-fits-all stress advice ignores this completely.
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Cortisol Receptor Sensitivity
Same cortisol level, very different felt experience. High receptor sensitivity means stress hits harder even when cortisol is "normal." This explains why some people thrive in chaos while others burn out—and it's not about being weak. It's about wiring.
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Sex Hormones
6 insights
hormone health
Dihydrotestosterone (DHT) Levels
DHT is the more potent downstream product of testosterone. High converters may see effects on hair loss, prostate health, or skin—and often benefit from DHT-blocking strategies before symptoms become problems. Low converters rarely need to worry about it.
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Estrogen Metabolism
Your liver processes estrogen through multiple pathways—some produce protective metabolites, others produce more aggressive ones. This ratio matters for long-term health and explains why some people feel great on the same hormone levels that cause problems for others. Cruciferous vegetables and targeted supplements can shift the balance.
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Estrogen Receptor Sensitivity
Same estrogen level, dramatically different response. High receptor sensitivity often underlies severe PMS, difficult perimenopause, or intense menopausal symptoms. It's not in your head—it's in your receptors.
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Luteinizing Hormone Production
LH is the pituitary signal that tells your body to produce testosterone or estrogen. Low pulsatility is a common root cause of low-T symptoms despite "normal" total testosterone—because the signal to produce more never fires strongly enough.
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Sex Hormone Binding Globulin (SHBG) Levels
SHBG binds sex hormones and takes them out of circulation. High levels can mask what's really low bioavailable testosterone or estrogen, even when total levels look fine. This is the "hidden half" that standard hormone panels ignore.
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Testosterone to Estrogen Conversion
Aromatase enzyme activity determines how much testosterone converts to estrogen. High converters—often signaled by weight around the middle—benefit from natural aromatase inhibitors like zinc, DIM, and weight training. Low converters rarely need to think about it.
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For practitioners
Using Hormone Health in clinical practice.
Expose T4→T3 conversion, receptor sensitivity, estrogen metabolism, and clearance pathways — giving you the missing data behind “normal labs, abnormal symptoms.”
About provider accounts →What to read next.
The 9 areas of your biology are interconnected: your appetite genes talk to your sleep genes, your detox pathways shape your hormone clearance. Each one informs the others.
See your hormone health insights.
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