Area 9 of 9 · 12 insights · Included with every kit
Hormones
Your labs say "normal." You feel anything but. Twelve insights on how you make, convert, and clear thyroid, cortisol, and sex hormones.
What you will see in this area.
Each one appears as a dark card in your Genomic Lifestyle Optimization Report, with a color marker set by your variants and a practical next step.
Thyroid
4 insights
Autoimmune Thyroid Risk
Genetic tendency toward Hashimoto's or Graves' varies widely. If you're in the higher-tendency group, it is worth knowing early and worth raising with your clinician, while lifestyle changes still have the most leverage.
Read insightDIO1 Activity
DIO1 handles the body-wide conversion of inactive T4 into active T3. Reduced activity is a common reason for persistent hypothyroid symptoms (fatigue, weight gain, cold intolerance) even when TSH looks "normal." Standard testing misses this entirely.
Read insightDIO2 Activity
DIO2 produces T3 specifically in the brain and muscles. Low activity is one of the most common causes of brain fog and cold hands on standard thyroid treatment that looks fine on paper. If your labs are normal but you still feel terrible, this is often why.
Read insightThyroid Stimulating Hormone (TSH) Levels
Your individual optimal TSH is often narrower than the lab reference range. Someone who feels best at 1.0 will feel terrible at 3.5, even though both are "normal." Knowing your sweet spot ends years of being told "you're fine" when you're clearly not.
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Cortisol & Stress
2 insights
Cortisol Production
Some people run naturally high on cortisol; others trend low. Neither is inherently bad, but each benefits from different stress-management strategies. High producers need more active recovery; low producers may need adaptogen support. One-size-fits-all stress advice ignores this completely.
Read insightCortisol Receptor Sensitivity
Same cortisol level, very different felt experience. High receptor sensitivity means stress hits harder even when cortisol is "normal." This explains why some people thrive in chaos while others burn out, and it's not about being weak. It's about wiring.
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Sex Hormones
6 insights
Dihydrotestosterone (DHT) Levels
DHT is the more potent downstream product of testosterone. High converters may see effects on hair loss, prostate health, or skin, and often want to know before symptoms show up. Low converters rarely need to worry about it.
Read insightEstrogen Metabolism
Your liver processes estrogen through multiple pathways. Some produce protective metabolites, others produce more aggressive ones. This ratio matters for long-term health and explains why some people feel great on the same hormone levels that cause problems for others. Cruciferous vegetables and targeted supplements can shift the balance.
Read insightEstrogen Receptor Sensitivity
Same estrogen level, dramatically different response. High receptor sensitivity often underlies severe PMS, difficult perimenopause, or intense menopausal symptoms. It's not in your head. It's in your receptors.
Read insightLuteinizing Hormone Production
LH is the pituitary signal that tells your body to produce testosterone or estrogen. Low pulsatility is a common root cause of low-T symptoms despite "normal" total testosterone, because the signal to produce more never fires strongly enough.
Read insightSex Hormone Binding Globulin (SHBG) Levels
SHBG binds sex hormones and takes them out of circulation. High levels can mask what's really low bioavailable testosterone or estrogen, even when total levels look fine. This is the "hidden half" that standard hormone panels ignore.
Read insightTestosterone to Estrogen Conversion
Aromatase enzyme activity determines how much testosterone converts to estrogen. High converters, often signaled by weight around the middle, benefit from natural aromatase inhibitors like zinc, DIM, and weight training. Low converters rarely need to think about it.
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What this area tells you.
Standard labs measure hormone levels. They do not show conversion, receptor sensitivity, or clearance rate. Your variants shape all three, which is often where "normal labs, abnormal symptoms" comes from.
You see what your labs have been missing: the conversion, sensitivity, and clearance patterns that help explain how you feel.
For practitioners
Hormones in clinical practice.
Show T4-to-T3 conversion, receptor sensitivity, estrogen metabolism, and clearance pathways: the data behind "normal labs, abnormal symptoms."
What to read next.
See this area in a real report.
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