When the labs are confusing and the symptoms are not.
Thyroid genetics aren’t one variant. They’re a pathway. T4→T3 conversion, thyroid receptor sensitivity, and the autoimmune-adjacent variants all matter. Mosaic reads the whole pathway, not the highlights.
Conversion: DIO1 (peripheral), DIO2 (tissue-specific) — how efficiently T4 becomes the active T3 your tissues use.
Receptor sensitivity: THR-A, THR-B — does your tissue respond loudly or quietly to the thyroid hormone you have?
Autoimmune-adjacent variants in the methylation and detoxification pathways that often co-occur in Hashimoto’s and Graves’.
Co-located reports: Hormone Health, Detoxification Pathways, Toxin Sensitivities — three deeply-related categories of the 9 in your report.
Defensible in clinical conversation. Designed to be read alongside thyroid labs by a functional medicine or endocrine clinician.
The genetic context behind your thyroid labs.
Mosaic scores DIO1, DIO2, thyroid-receptor variants, and the methylation/detox-pathway cofactors that affect thyroid hormone clearance — each shown as a personalized dark card with a color marker and practical guidance.
See a real report