Why your DAO levels matter, even on a low-histamine diet.
Histamine clearance is genetic. The DAO and HNMT enzymes that break histamine down vary across people, and so does sensitivity to environmental triggers. Mosaic reads the genes that shape that whole pathway.
DAO (AOC1): the primary enzyme that breaks down dietary histamine in your gut.
HNMT: the methylation-dependent enzyme that clears histamine inside cells.
MAO-B: secondary clearance.
Connected pathways: methylation (MTHFR, COMT), detoxification, and the environmental-toxin sensitivity genes that often co-occur.
Practical: which dietary triggers, supplements, and environmental factors map to your genetics — not generic advice.
See your histamine-clearance settings, not generic guidance.
Mosaic’s Toxin Sensitivities and Detoxification reports together cover histamine clearance, environmental-toxin reactivity, and methylation: the three layers that drive histamine-related symptoms. Each variant scored against your DNA, with a color marker per insight.
See a real report