Vitamin E Inflammation Propensity
One of 108 insights in your Genomic Lifestyle Optimization Report.
High-dose vitamin E lowers inflammation in most people, but raises it in a genetic minority. Knowing your response prevents the difference between a helpful supplement and one that's quietly making things worse.
How your DNA shapes vitamin E inflammation propensity.
CD36 codes for a fatty-acid receptor that influences inflammatory signaling, and interacts with how vitamin E modulates that signaling. TNF-α and related inflammatory cytokine pathways shape whether supplemental vitamin E at higher doses acts anti-inflammatory or pro-inflammatory in a given client.
Carriers of certain CD36 variants are associated with anti-inflammatory benefit from supplemental vitamin E at moderate-to-high doses. Carriers of other variant combinations are associated with the opposite response: vitamin E supplementation can raise inflammatory markers and may not be the supportive antioxidant it’s marketed as. The pattern is one of the cleanest examples of pharmacogenomic individualization at the nutrient level.
Whole-food vitamin E from nuts, seeds, and leafy greens delivers the nutrient in context (alongside other antioxidants, fiber, and fats) and rarely produces the pro-inflammatory response that isolated high-dose supplementation can trigger. Omega-3 status, vitamin C levels, and overall antioxidant balance all shift how the body handles supplemental vitamin E.
"Take vitamin E for inflammation" is the right move for some clients and the wrong one for others. Which CD36 variant pattern you carry decides whether higher-dose supplementation is supportive, or whether the food-only approach is the safer default.
In your report, Vitamin E Inflammation Propensity is one dark card: a color marker set by your variants, the mechanism in plain language, and one practical next step.
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Fat-Soluble Vitamins: the 7-insight cluster.
Vitamin E Inflammation Propensity is one finding in a tightly related cluster. Mosaic reads the other 6 alongside it, so you see the whole biology, not an isolated data point.
About Vitamin E Inflammation Propensity.
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Read insightThis is one of 108. Your report reads all of them, from one cheek swab.
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