Detoxification Pathways
MTHFR Enzyme Activity
Example result: 25% Enzyme Activity · Action recommended
Your MTHFR enzyme operates at roughly a quarter of normal capacity. A significant reduction that creates meaningful challenges in folate conversion and downstream methylation. Your body does convert some folate through this pathway, but not nearly enough to meet demand without support.
What to do: Supplement with methylfolate to compensate for your limited enzyme function. Ensure adequate B12 (as methylcobalamin) and magnesium to support the methylation processes that depend on active folate. Avoid synthetic folic acid in fortified foods and supplements, as it places additional burden on an already strained conversion pathway. Work with a healthcare provider to monitor methylation markers and adjust your approach based on your response.











