Magnesium Runs 300+ Enzymes in Your Body — Here's How Genetics Sets Your Need

Magnesium is involved in over 300 enzymatic reactions — muscle function, nerve signaling, energy production, DNA synthesis, blood pressure, sleep — and it's still one of the most common deficiencies. Your genetics influence both how much magnesium your body actually needs and how well it holds onto it, which is why the standard recommendation isn't the right target for everyone.

Why some people need more

Genes like TRPM6 and TRPM7 code for magnesium transport channels in your intestines and kidneys. Variants in these genes can affect how efficiently you absorb magnesium from food and how well your kidneys retain it. If your genetics favor faster excretion or lower absorption, you may need more magnesium than the average recommendation suggests.

This is especially relevant because magnesium status is notoriously hard to measure through standard blood tests. Most of your body's magnesium is stored in bones and soft tissues, not in the blood. So a "normal" serum magnesium level doesn't always mean your cells have enough. Genetic data adds a useful layer of context.

Signs your body might want more

Muscle cramps, poor sleep, restless legs, tension headaches, and difficulty relaxing can all be associated with suboptimal magnesium levels. These symptoms are common and have many possible causes, but magnesium is one of the first things worth investigating, especially if your genetics suggest a higher-than-average need.

What Mosaic covers

Your Mosaic report includes a magnesium need reading in the Micronutrients section. It reflects your genetic tendency for magnesium absorption and retention. Combined with how you feel and any relevant lab work, it helps you and your practitioner decide whether supplementation makes sense and at what level.